1008-75-9, Name is 3-Methyl-5-phenylisoxazole, belongs to Isoxazoles compound, is a common compound. Application In Synthesis of 3-Methyl-5-phenylisoxazoleIn an article, once mentioned the new application about 1008-75-9.
Direct synthesis of 4-fluoroisoxazoles through gold-catalyzed cascade cyclization-fluorination of 2-alkynone O-methyl oximes
A tandem protocol for the synthesis of fluorinated isoxazoles has been developed via catalytic intramolecular cyclizations of 2-alkynone O-methyl oximes and ensuing fluorination. The reactions proceed smoothly at room temperature in the presence of 5 mol % of (IPr)AuCl, 5 mol % of AgOTs, 2.5 equiv of Selectfluor, and 2 equiv of NaHCO3. This process features an efficient one-pot cascade route to fluoroisoxazoles with high yields and high selectivity under mild reaction conditions.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem