Electric Literature of 168828-90-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 168828-90-8, Name is (S)-5-(Aminomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one, SMILES is O=C1O[C@@H](CN)CN1C2=CC=C(N3CCOCC3)C(F)=C2, belongs to Isoxazoles compound. In a article, author is Fu, Meiqiang, introduce new discover of the category.
Synthesis of 3-Nitroisoxazoles via Copper Acetate-Mediated Reaction of Benzaldehydes with Nitromethane
A copper acetate-mediated reaction of benzaldehydes with nitromethane to synthesis of 3-nitroisoxazoles is reported. A variety of nitro-aryl-disubstituted isoxazole derivatives can be prepared in moderate to good yields with benign functional group tolerance. This protocol is successfully applied in gram-scale reaction. Preliminary mechanistic studies reveal that the aldehyde provided one carbon atom for the isoxazole ring, and nitromethane provided two carbon atoms and one nitrogen atom for the isoxazole ring. In this protocol, the C-O-N unit in the final isoxazole ring is formed from the rearrangement of nitromethane.
Electric Literature of 168828-90-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 168828-90-8.
Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem