Anand, Mohanam; Selvaraj, Vaithialingam; Alagar, Muthukaruppan published the artcile< Synthesis, characterization and evaluation of antioxidant and anticancer activities of novel benzisoxazole-substituted-allyl derivatives>, Recommanded Product: Benzo[d]isoxazol-3-ol, the main research area is allylbenzisoxazolone preparation antioxidant anticancer activity human green chem; benzoisoxazolone allyl bromide chloride cesium carbonate catalyst.
A novel series of various 2-allylbenzo[d]isoxazol-3(2H)-ones I [R = allyl, cinnamyl, benzyl, etc.] were synthesized using benzo[d]isoxazol-3(2H)-one treated with different allyl bromides/chlorides in the presence of water-mediated cesium carbonate as a new catalyst. The structures of the allylated benzisoxazolones I were characterized by spectroscopic methods and mass spectrometry. These synthesized compounds I were evaluated for their in vitro antioxidant and anticancer activity. Compounds I [R = 2-pentynyl, 3-methyl-2-butenyl, benzyl, 4-phenyl-2-butynyl] were identified as the best hit against HT-29 Human colon cancer cells, and showed significant antioxidant activity compared to the standard drug butylated hydroxy toluene (BHT).
Korean Journal of Chemical Engineering published new progress about Allylic halides Role: RCT (Reactant), RACT (Reactant or Reagent) (bromides, chlorides). 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Recommanded Product: Benzo[d]isoxazol-3-ol.
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem