With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.954230-39-8,Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate,as a common compound, the synthetic route is as follows.,954230-39-8
Step d) r3-(4-Fluorophenyl)-5-methyl-isoxazol-4-yll -methanol Alternative 2) Preparation by reduction of the ethyl ester (i) with L1AIH4 as reducing agent: To a suspension of LiAlH4 (75.9 mg, 2.0 mmol) in THF (2 mL) was added at 0-10C within 15 minutes a solution of 3-(4-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (0.50 g, 2.0 mmol) in THF (3 mL) and the resulting solution was allowed to warm to room temperature and subsequently stirred at this temperature for at least one hour. Water (15 mL) was added dropwise and the resulting suspension was then filtered and the filter cake washed with ethyl acetate (15 mL). From the biphasic filtrate the layers were separated and the organic layer was washed with water (1×15 mL). Both combined aqueous layers were back extracted with ethyl acetate (2×15 mL). The combined organic layers were dried over Na2S04 and subsequently concentrated to dryness (45C/25 mbar) to afford 0.375 g (90%) of the title compound as a slightly yellow solid with a purity of 100% (by HPLC).
The synthetic route of 954230-39-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius; WO2013/57123; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem