Analyzing the synthesis route of 62348-13-4

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.

62348-13-4, Example 91 N-{[1 ,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1 H-pyrazolo[3,4- b]pyridin-5-yl]methyl}-5-isoxazolecarboxamideA solution of Intermediate 16 (75mg) in anhydrous acetonitrile (1.25ml) was treated with isoxazole-5-carbonyl chloride (33mg) and DIPEA (0.044ml) and stirred at room temperature for 24 hours. The solution was diluted with dichloromethane (10ml), washed with dilute aqueous sodium chloride (2 x 7ml) and evaporated in vacuo to give Example 91 as a yellow sold (104mg). LCMS showed MH+ = 399; TREtau = 1 -98min.

The synthetic route of 62348-13-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/36733; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem