With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35166-33-7,3-Hydroxymethyl-5-methylisoxazole,as a common compound, the synthetic route is as follows.
Example 22 3- [ (4-METHOXYPHENYL) AMINO]-1- [ (5-METHYLISOXAZOL-3-YL) METHYL]-4-PHENYL-LH-PYRROLE- 2,5-dione To a solution of 3- [ (4-methoxyphenyl) amino]-4-phenyl-lH-pyrrole-2, 5-dione (0.17 mmol, 50 mg), 5-methylisoxazole-3-methanol (0.19 mmol, 21 mg) and diethyl azodicarboxylate (0.19 mmol, 33 mg) in dry THF (1 mL) was added triphenylphosphine (0.19 mmol, 49 mg) in dry THF (1 mL). The mixture was heated in a microwave reactor at 130C for six min.. After cooling, the reaction mixture was purified by HPLC (95% 0. 1M ammonium acetate buffer: 5% CH3CN E 100% CH3CN) to give 14 mg (21%) of the title compound. IH NMR (400 MHz, CDCL3) 6 7.23 (bs, 1H), 7. 16-7. 06 (m, 3H), 7. 01-6. 96 (m, 2H), 6.63-6. 53 (m, 4H), 6. 03 (d, J=0.7 Hz, 1H), 4. 82 (s, 2H), 3.70 (S, 3H), 2.39 (d, J=0.7 Hz, 3H)., 35166-33-7
The synthetic route of 35166-33-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; WO2005/5417; (2005); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem