With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
A mixture of 3, 5-dimethyl-isoxazole-4-carboxylic acid (8.1 mg, 0.057 mmol) in dichloromethane (1.5 mL) cooled to [0 oC] was treated with triphenylphosphine (17 mg, 0.063 mmol), and N-chlorosuccinimide (10 mg, 0.074 mmol). This mixture was stirred at [0 oC] for 15 min and at [25 oC] for 20 min. At this time, the reaction was treated with [3-CYCLOPROPYLMETHYL-L- (2-FLUORO-BENZYL)-8- (4-METHYLAMINO-BENZYL)-3,] 7- dihydro-purine-2,6-dione (50 mg, 0.11 mmol). The reaction was then stirred at [25 oC] for 18 h. At this time, the reaction was diluted with dichloromethane (50 mL) and was washed with a saturated aqueous sodium bicarbonate solution [(1 X 10] mL). The organics were dried over magnesium sulfate, filtered, and concentrated in vacuo. Flash chromatography (Merck Silica gel 60,230-400 mesh, 2: 98 methanol/ dichloromethane) afforded 3,5-dimethyl-isoxazole-4-carboxylic acid [{4- [3-] [CYCLOPROPYLMETHYL-L-(2-FLUORO-BENZYL)-2,] 6-dioxo-2,3, 6, 7-tetrahydro-lH-purin-8- ylmethyl] -phenyl} -methyl-amide (7.4 mg, 23.2%) as an off-white solid
2510-36-3, The synthetic route of 2510-36-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2003/106459; (2003); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem