With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21169-71-1,Isoxazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.,21169-71-1
Part 2. Amide coupling. Crude 32 (TJF-5) was synthesized from amine intermediate 31 (21.5?mg, 0.05?mmol) and isoxazole-5-carboxylic acid (7.3?mg, 0.06?mmol) according to general method D. The crude material was dissolved in a minimal amount of DCM, loaded onto a 10?g silica gel column, and purified by flash chromatography (MeOH/DCM, 0-5%) to give 32 48 (9.1?mg) as a white solid in 16% yield over 2 steps. LC/MS tR?=?6.46?min (Characterization Method A); m/z?=?499.00 (M+H+), 521.00 (M+Na+), 498.25 (M – H+), 543.25 (M+formic acid adduct); 1H NMR (300?MHz, CDCl3) delta?=?8.32 (d, J?=?1.5?Hz, 1H), 7.30 (s, 1H), 7.33-7.21 (m, 1H), 6.96-6.82 (m, 4H), 6.46 (app t, J?=?5.6?Hz, 1H), 4.74 (dd, J?=?8.5?Hz, 1H), 4.44 (ddd, J?=?8.8, 20.8?Hz, 2H), 4.27 (t, J?=?7.6?Hz, 1H), 3.86 (s, 3H), 1.89-1.73 (m, 3H), 1.72-1.58 (m, 7H), 1.52-1.38 (m, 1H), 1.37-1.24 (m, 2H), 1.22-1.02 (m, 4H), 0.98-0.88 (m, 2H), 0.88-0.79 (m, 6H).
The synthetic route of 21169-71-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Gandhi, Disha M.; Majewski, Mark W.; Rosas, Ricardo; Kentala, Kaitlin; Foster, Trevor J.; Greve, Eric; Dockendorff, Chris; Bioorganic and Medicinal Chemistry; vol. 26; 9; (2018); p. 2514 – 2529;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem