With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131052-47-6,(3,5-Dimethylisoxazol-4-yl)methanamine,as a common compound, the synthetic route is as follows.
A mixture of (3,5-dimethylisoxazol-4-yl)methanamine (70 mg, 0.6 mmol), 4- phenoxycarbonylamino-benzoic acid ethyl ester (150 mg, 0.5 mmol) and TEA (0.2 mL, 1.6 mmol) in MeCN (8 mL) was stirred at 80 C for 1 h and then concentrated. The residue was diluted with DCM (40 mL), washed with aq.HC1 (1 N, 20 mL) and Sat.NaHCO3 (20 mL). The DCM solution was dried over Na2SO4, concentrated and purified by Prep-HPLC (NH3.H20) to give ethyl 4-(3-((3,5- dimethylisoxazol-4-yl)methyl)ureido)benzoate (50 mg, yield: 30%) as a white solid. ?H NIVIR (400 IVIHz, DMSO-d6): oe = 8.85 (s, 1H), 7.82 (d, J= 8.8 Hz, 2H), 7.50 (d, J 8.8 Hz, 2H), 6.64 (t, J 5.6 Hz, 1H), 4.26 (q, J= 7.2 Hz, 2H), 4.06 (d, J= 5.6 Hz, 2H), 2.38 (s, 3H), 2.21 (s, 3H), 1.29 (t, J 7.2 Hz, 3H). MS: m/z 318.0 (M+H).
131052-47-6, The synthetic route of 131052-47-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
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