With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1136-45-4,5-Methyl-3-phenylisoxazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of 5-methyl-3-phenyl-isoxazole-4-carboxylic acid (5.00 g, 24.6 mmol) in THF (50 mL) was added in one portion l,l’-carbonyl-diimidazole (4.39 g, 27.1 mmol). After stirring for 15 min at ambient temperature the solution was warmed to 70 0C and stirred for 30 min at this temperature. After the solution was cooled to 0 0C hydrazine monohydrate (2.4 mL, 49.0 mmol) was added over a period of 2 min while the temperature raised to 15 0C. The resulting suspension was stirred for 30 min at 0 0C. After addition of 20 mL heptane the suspension was stirred for 15 min at 0 0C and filtered off. Washing with water and drying afforded the title compound (4.52 g, 85%) as a white solid. MS: m/e = 218.2 [M+H]+.
The synthetic route of 1136-45-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2007/71598; (2007); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem