With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1136-45-4,5-Methyl-3-phenylisoxazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
1136-45-4, A solution of 3-phenyl-5-methyl-4-isoxazole formic acid (0.2 g, 1 mmol) in DMF (5 mL) was stirred. EDCI (1-(3-dimethylamino propyl)-3-2 ethyl carbon imine hydrochloride) (0.22 g, 1.2 mmol) and HOBt (N-hydroxybenzotrizole) (0.16 g, 1.2 mmol) were added sequentially and activated for approximately 1 h. Glucosamine hydrochloride (0.43 g, 2 mmol) and triethylamine (0.4 g, 4 mmol) were then added, and the solution was stirred for an additional 24 h at room temperature. The reaction was monitored by TLC. The mixture was extracted with ethyl acetate (EA) after the end of the reaction. The organic layer was separated, washed with a saturated sodium chloride solution, dried over MgSO4, and concentrated in vacuo. The residue was washed with ethanol/dichloromethane (v/v = 2:5), and the title compound A1 was obtained as a white solid (70% yield). 1H NMR (400 MHz, DMSO) delta 8.27 (m, 2H), 7.65 (m, 3H), 6.60 (s, 1H, NH-CO), 5.04 (d, 1H), 3.58 (m, 2H), 3.30 (d, J = 25.2 Hz, 2H), 3.05 (q, J = 7.3 Hz, 1H), 2.53 (d, J = 3.6 Hz, 3H, CH3), 1.18 (s, 4H, OH). 13C NMR (100 MHz, DMSO-d6) delta 169.75, 161.44, 159.95, 128.71, 127.83, 112.85, 90.29, 72.10, 71.12, 70.12, 61.01, 54.80, 45.26, 10.93, 8.37. HRMS (ESI) calcd for C17H20N2O7 [M+Na]+: 387.1179, found 387.1166.
The synthetic route of 1136-45-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Cao, Tingting; Li, Yong; Jiang, Lijuan; Yuan, Li; Dong, Lin; Li, Ying; Yin, Shufan; Carbohydrate Research; vol. 433; (2016); p. 73 – 79;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem