With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.
EXAMPLE 1 SPC10 3-(Chloroacetamido)-5-Methylisoxazole To 800 ml of chloroform is added 118 grams (1.12 moles) of 3-amino-5-methylisoxazole followed by 118 grams (1.5 moles) of pyridine. To this solution is added 147 grams (1.3 moles) of chloroacetylchloride with the addition temperature maintained at 0-10C. The reaction is then stirred at room temperature for 1 hour, filtered and dried in a vacuum desiccator to give 116 grams (56%) of 3-(chloroacetamido)-5-methylisoxazole, mp 192-195C. This material is slightly irritating to the skin and due caution should be exercised. Anaylsis: Calc’d for C6 H7 ClN2 O2 (174.58): C, 41.28; H, 4.04; N, 16.05; Cl, 20.31. Found: C, 41.55; H, 4.10; N, 15.79; Cl, 20.50., 1072-67-9
The synthetic route of 1072-67-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Warner-Lambert Company; US3957772; (1976); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem