In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study, published in 2020, which mentions a compound: 3235-67-4, Name is 1-Piperidineacetic Acid, Molecular C7H13NO2, SDS of cas: 3235-67-4.
A series of potent HIV-1 protease inhibitors, containing diverse piperidine analogs as the P2-ligands, 4-substituted phenylsulfonamides as the P2′-ligands and a hydrophobic cyclopropyl group as the P1′-ligand, were designed, synthesized and evaluated in this work. Among these twenty-four target compounds, many of them exhibited excellent activity against HIV-1 protease with half maximal inhibitory concentration (IC50) values below 20 nM. Particularly, compound I containing a (R)-piperidine-3-carboxamide as the P2-ligand and a 4-methoxylphenylsulfonamide as the P2′-ligand exhibited the most effective inhibitory activity with an IC50 value of 3.61 nM. More importantly, I exhibited activity with inhibition of 42% and 26% against wild-type and Darunavir (DRV)-resistant HIV-1 variants, resp. Addnl., the mol. docking of I with HIV-1 protease provided insight into the ligand-binding properties, which was of great value for further study.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem