Alberola, A. et al. published their research in Synthesis in 1988 | CAS: 5765-44-6

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazoles also form the basis for a number of drugs, including the COX-2 inhibitor valdecoxib (Bextra) and a neurotransmitter agonist AMPA. Some alternative routes for the synthesis of isoxazoles have also been developed and reported. The 2-benzoyl-2-halo-2H-azirines provide 4-haloisoxazoles in good yields after heating in toluene at reflux temperature.Reference of 5765-44-6

The reactions of 3-unsubstituted isoxazolium salts with 1,2-dinucleophiles. Synthesis of 4-functionalized 3-aminoisoxazoles with 3-aminopyrazoles was written by Alberola, A.;Antolin, L. F.;Cuadrado, P.;Gonzalez, A. M.;Laguna, M. A.;Pulido, F. J.. And the article was included in Synthesis in 1988.Reference of 5765-44-6 This article mentions the following:

Cyclization of isoxazolium salts I (R1 = Me, Ph; R2 = Et, Me3C; R3 = H, Cl, Br, NO2, Ac, CO2Et; X = ClO4, BF4) with NH2OH or RNHNH2 (R = H, Me, Ph, p-O2HC6H4, CONH2) gave 42-98% 66 II (Z = O, RN), resp. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6Reference of 5765-44-6).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazoles also form the basis for a number of drugs, including the COX-2 inhibitor valdecoxib (Bextra) and a neurotransmitter agonist AMPA. Some alternative routes for the synthesis of isoxazoles have also been developed and reported. The 2-benzoyl-2-halo-2H-azirines provide 4-haloisoxazoles in good yields after heating in toluene at reflux temperature.Reference of 5765-44-6

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem