288-14-2, Name is Isoxazole, belongs to isoxazole compound, is a common compound. SDS of cas: 288-14-2In an article, once mentioned the new application about 288-14-2.
Synthesis and biological evaluation of novel 1,8-Naphthyridines containing pyrazolinone, pyrazole, isoxazolinone, isoxazole and pyrimidine-2-ones
Diazonium salt of 2-(p-aminophenyl)-1,8-naphthyridine (I) was coupled with active methylene compounds to afford the hydrazono-1,8-napthyridinyl (III-V) and azo(VI) derivatives. Hydrazono ethyl acetoacetate (III) and ethyl cyanoacetate (IV) derivatives on treatment with hydrazine and substituted hydrazine’s were later reacted with hydroxylamine HCl in the presence of ethanol followed by cyclization to afford pyrazolinone (IIIa-e) and (IVa-e) and isoxazolinones (VII and IX). Hydrazono acetyl acetone (V) and azo dibenzoyl methane (VI) derivatives on treatment with hydrazine and substituted hydrazines, hydroxylamine HCl and with urea in the presence of ethanol followed by cylization resulted in the formation of pyrazoles (Va-e) and (VIa-e), isoxazole (IX and XI) and substituted pyrimidine-2-ones (X and XII). All the newly synthesized compounds were screened for their in-vitro antibacterial activity and antifungal activity by Agar cup-plate method and Serial dilution methods. In Agar cup plate method the Compounds IIId, IVd, VId showed Impressive antibacterial and antifungal activity. In Serial dilution method the compounds Vd and VId showed excellent antibacterial activity against B.Subtilis with an MIC of 7.8 and mug/ml where as the compounds IVd, Vd showed very good antifungal activity against A.niger and C.albicans with MIC value of 7.8 and mug/ml and 15.6 and mug/ml. We found that the activity was due to presence of chloro group at the para position of phenyl ring of Pyrazolinone and pyrazole and also the presence of methyl group and amino group at the 3rd position, hydrazono and azo (N=N) group at 4th of the pyrazolinone (IIId, IVd) and pyrazole (Vd) ring are contributing to the antimicrobial activity.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem