SDS of cas: 14248-66-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3,5-Dimethyl-4-nitropyridine 1-oxide, is researched, Molecular C7H8N2O3, CAS is 14248-66-9, about Studies on chemical carcinogens. XV. Carcinogenicity and mutagenicity of 4-nitropyridine 1-oxide derivatives. Author is Takahashi, Kazuhiko; Huang, Guang-Fu; Araki, Misako; Kawazoe, Yutaka.
The carcinogenicity and mutagenicity of 4-nitropyridine 1-oxide (I) [1124-33-0] and 7 of its alkyl derivatives were tested on mice and on Salmonella typhimurium strains and Escherichia coli strains. 3-Methyl compound [1074-98-2] was the most potent carcinogen, followed by 3-ethyl [35363-12-3] and then I. The mutagenicity was the most potent in 3-methyl derivative, 2,3-dimethyl [37699-43-7], and 2,5-Dimethyl [21816-42-2], moderate in I,and 2-Methyl [5470-66-6] and 2,6-dimethyl [4808-64-4], and to a least extent in 3,5-dimethyl [14248-66-9] derivative of I. Structure-mutagenicity relation was discussed on the basis of the mol. mechanism of the carcinogenesis of I. Quant. relation between mutagenicity and carcinogenicity was not strictly found among the compounds examined
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem