The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 1076-97-7, Name is 1,4-Cyclohexanedicarboxylic acid, SMILES is O=C(O)C1CCC(CC1)C(O)=O, in an article , author is Lee, Yoon-Suk, once mentioned of 1076-97-7, Category: Isoxazoles.
C5-Modified nucleosides exhibiting anticancer activity
We describe (i) a simple method for the synthesis of C5-modified nucleosides from 5-iodo-2’deoxyuridine and (ii) their activity against six types of human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN). We generated nitrile oxides in situ from oximes using a commercial bleaching agent; their cycloadditions with 5-ethynyl-2′-deoxyuridine yielded isoxazole derivatives possessing activity against the cancer cell lines. We synthesized several azides from benzylic bromides and their click reactions with 5-ethynyl-2′-deoxyuridine provided triazole derivatives. (C) 2009 Elsevier Ltd. All rights reserved.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem