With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1072-67-9,5-Methylisoxazol-3-amine,as a common compound, the synthetic route is as follows.
General procedure: A solution of Aryl-or heteroary-amine (1.0 mol) in chloroformor dichloromethane was stirred with potassium carbonate(1.5 mol). To this solution was then added 1.5 mol of chloroacetylchloride under cold. Reaction was stirred overnight at room temperature.After completion of reaction (monitored by TLC), solventwas removed under reduced pressure. To the solid mass, ice coldwater was added. The solid thus obtained was then filtered driedand recrystallized from ethanol., 1072-67-9
1072-67-9 5-Methylisoxazol-3-amine 66172, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Article; Bhanushali, Umesh; Rajendran, Saranya; Sarma, Keerthana; Kulkarni, Pushkar; Chatti, Kiranam; Chatterjee, Suvro; Ramaa; Bioorganic Chemistry; vol. 67; (2016); p. 139 – 147;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem