3209-71-0, Isoxazole-3-carboxylic Acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3209-71-0, [0328] To a solution of isoxazole-3-carboxylic acid (100 mg, 0.88 mmol, 1 equiv) in DMF (1 mL), were added HATU (369 mg, 0.97 mmol, 1.1 equiv). The mixture was treated drop wise with DIPEA (365 mg, 2.83 mmol, 3.2 equiv). After stirring at RT for l5minutes, the mixture was treated drop wise with a solution of l-(2,4-bis(trifluoromethyl)benzyl)-lH- pyrazol-4-amine (273 mg, 0.884 mmol, 1 equiv) in DMF (1 mL). The reaction mixture was kept under stirring for 24 h at RT. Product formation was confirmed with TLC & LCMS and reaction mixture was diluted EtOAc (50 mL) & washed with water (50 mL X 2). Organic layer dried over Na2S04 & concentrated under reduced pressure to obtain crude which was further purified by flash column chromatography to obtain pure product N-(l-(2,4- bis(trifluoromethyl)benzyl)-lH-pyrazol-4-yl)isoxazole-3-carboxamide. (40 mg, 11% as off white solid). XH NMR (400 MHz, DMSO-c/6) d 11.06 (s, 1H), 9.14 (d, J= 1.5 Hz, 1H), 8.29 (s, 1H), 8.06 (d, J= 8.3Hz, 2H), 7.76 (s, 1H), 7.05 (d,.7= 8.1Hz, 1H), 6.99 (d, J= 1.7 Hz, 1H), 5.66 (s, 2H).
3209-71-0 Isoxazole-3-carboxylic Acid 11286453, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; PRAXIS BIOTECH LLC; ALFARO, Jennifer; BELMAR, Sebastian; NUNEZ VASQUEZ, Gonzalo Esteban; PUJALA, Brahmam; SATHE, Balaji Dashrath; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; THAKRAL, Pooja; PATIDAR, Rajesh Kumar; (344 pag.)WO2019/195810; (2019); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem