1072-67-9, 5-Methylisoxazol-3-amine is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Sodium nitrite (0.14 g, 2.0 mmol) was added portion-wise to 3.0 mL of sulfuric acid at 15 C and heated to 60 C with stirring for 20 min. The solution was cooled to below 5 C and a mixture of acetic and propionic acids (5:1, 3 mL) were added at below 25 C. The finely heterocyclic amine derivatives (2.0 mmol) were slowly added, within 25 min below 5 C, and the whole mixture was stirred at 0-5 C for 2 h. After completion of diazotization procedure, the diazonium salt solution was added drop-wise to the solution of 6-amino-1,3-dimethyluracil (2.0 mmol, 0.31 g) in sodium hydroxide (4.0 mmol, 0.16 g) and water (5.0 mL). The resulting solution was vigorously stirred at 0-5 C for 1 h and the progress of the reaction was followed by TLC, using an ethyl acetate-petroleum ether mixture (4:1 v/v) as developing solvent. After neutralizing the residual HCl and filtration, the product was crystallized from DMF. The physical and spectral data of the purified dyes are as follows.
1072-67-9, The synthetic route of 1072-67-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Yousefi, Hessamoddin; Yahyazadeh, Asieh; Yazdanbakhsh, Mohammad Reza; Rassa, Mehdi; Moradi-E-Rufchahi, Enayat O’Llah; Journal of Molecular Structure; vol. 1015; (2012); p. 27 – 32;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem