With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14678-02-5,5-Amino-3-methylisoxazole,as a common compound, the synthetic route is as follows.
General procedure: A solution of 2-(chloroseleno)benzoyl chloride (1 mmol) in dryether (10 mL) was added dropwise over 30 min to a stirred solution ofthe appropriate amine (1.2 mmol) and triethylamine (3.5 mmol) in dryDCM (10 mL) at 0 C. The reaction mixture was stirred at room temperatureovernight. The solvent was removed under reduced pressureand the residue was washed with water (20 mL), and extracted withDCM (3¡Á10 mL). The combined organic extracts were dried over anhydrousMgSO4, the solvent removed was under reduced pressure, andthe crude product was purified by flash column chromatography onsilica gel (eluents: 10-50% ethyl acetate in petroleum gradient) [31].All EB analogues except 4c and 4e have been reported., 14678-02-5
The synthetic route of 14678-02-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Chen, Cheng; Yang, Kewu; Bioorganic Chemistry; vol. 93; (2019);,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem