With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7063-99-2,Ethyl 5-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
7063-99-2, General procedure: Sodium hydroxide (2N) was added to a solution of intermediate 2a-i (1 equiv.) in methanol at ambient temperature. The reaction mixture was stirred for 4h and the methanol was removed by rotary evaporation. The resultant mixture was adjusted to pH=5-6 with 1N HCl solution. The precipitated white solid was collected by filtration and dried to give the carboxylic acid intermediate (1a-i). 4.13.1 5-Phenylisoxazole-3-carboxylic acid(1a) (0032) Light white solid; yield: 91.5%; 1H NMR (600MHz, DMSO-d6) delta 7.95 (dd, J=7.8, 1.7Hz, 2H), 7.58-7.53 (m, 3H), 7.41 (s, 1H).
As the paragraph descriping shows that 7063-99-2 is playing an increasingly important role.
Reference£º
Article; Zhao, Shizhen; Zhang, Xiangqian; Wei, Peng; Su, Xin; Zhao, Liyu; Wu, Mengya; Hao, Chenzhou; Liu, Chunchi; Zhao, Dongmei; Cheng, Maosheng; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 96 – 107;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem