With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51677-09-9,Methyl 5-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
51677-09-9, To a solution of 1-2 (1.0 g, 4.9 mmol) in MeOH (10 mL) was added sodium hydroxide solution (20 mL, 4 M). The reaction mixture was stirred at room temperature for 2 hours and concentrated under reduced pressure to remove MeOH. The aqueous phase was acidified with aqueous HCl (1 M) till pH=3 and the mixture was extracted with EtOAc, dried with anhydrous Na2SO4, filtered and concentrated to give the crude product. The crude product was purified by silica gel chromatography eluted to give product 1-2 (0.7 g, 79.5%). MS m/z [ESI]: 190.0 [M+1].
The synthetic route of 51677-09-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUZHOU SINOVENT PHARMACEUTICALS CO., LTD.; WANG, Yonghui; ZHU, Yan; ZHOU, Juan; GAO, Yujun; WANG, Shiqun; WANG, Dong; LIU, Wandeng; SHEN, Ximing; HONG, Binbin; LIU, Tao; WU, Yaodong; LI, Chunqi; (35 pag.)US2018/271846; (2018); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem