946426-89-7, 5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazole-4-methanol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 6: Ethyl 5-(4-(2-chloro-4-((5-cvclopropyl-3-(2,6-dichlorophenvnisoxazol-4- yl)methoxy)phenyl)-4-hvdroxypiperidin-1 -yl)-1 -isopropyl-1 /-/-pyrazole-3-carboxylate (39f) To a suspension of intermediate 39e (230 mg, 0.56 mol), (5-cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4-yi)methanol (158 mg, 0.56 mol) and PPh3 (239 mg, 1.1 mmol) in toluene (10 ml) was added DIAD (226 mg, 1.1 mmol) dropwise at 0C. The resulting mixture was stirred at rt for 4 h. The reaction mixture was diluted with H20, extracted with EtOAc (20 mL x 3) and the organic layers were concentrated to dryness. The residue was and purified by preparative TLC (EtOAc/PE=1/1 ) to give the title compound (220 mg)., 946426-89-7
The synthetic route of 946426-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KROPF, Jeffrey, E.; SCHMITT, Aaron; WATKINS, William, J.; XU, Jianjun; GEGE, Christian; (92 pag.)WO2016/96116; (2016); A1;,
Isoxazole – Wikipedia
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