With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36958-61-9,5-(Bromomethyl)-3-methylisoxazole,as a common compound, the synthetic route is as follows.,36958-61-9
STR613 Ethylenediamine (30 g) was dissolved in 120 g of acetonitrile, and a solution of 17.6 g of 5-bromomethyl-3-methylisoxazole in 30 ml of acetonitrile was added dropwise at 5 to 10 C. After the addition, the mixture was stirred for 1 hour with a care taken not to permit the temperature of the reaction system to rise above 20 C. Then, most of the volatile materials were removed under vacuum (less than 2 mmHg) while maintaining the bath temperature at 20 C. Ice water was added to the residue, and the mixture was extracted with dichloromethane. The dichloromethane layer was dehydrated, and dichloromethane was distilled off under reduced pressure to give 10.0 g of N-(3-methyl-5-isoxazolylmethyl)ethylenediamine (purity about 95%) as a colorless oil. NMR spectrum (delta in CDCl3): NH, NH2: 1.47 (ppm), –CH2 CH2: 2.23, –CH3: 2.7, –CH2 –: 5.8, Hetero-H: 5.9.
As the paragraph descriping shows that 36958-61-9 is playing an increasingly important role.
Reference£º
Patent; Nihon Tokushu Noyaku Seizo K. K.; US4742060; (1988); A;,
Isoxazole – Wikipedia
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