Goasdoue, Claude et al. published their research in Tetrahedron Letters in 1979 | CAS: 5765-44-6

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.SDS of cas: 5765-44-6

Preparation of β-oxo nitriles through acylation of trimethylsilyl cyanoacetate by mixed anhydrides was written by Goasdoue, Claude;Couffignal, Rene. And the article was included in Tetrahedron Letters in 1979.SDS of cas: 5765-44-6 This article mentions the following:

Treating Me3SiO2CCHLiCN (I) and EtCHLiCN with RCO2CO2Et (R = Pr, Ph) gave 59 and 74% RCOCH2CN, and 55 and 74% RCOCHEtCN, resp. I was prepared by treating HO2CCH2CN with Me3SiCl (90%) followed by lithiation. In the experiment, the researchers used many compounds, for example, 5-Methylisoxazole (cas: 5765-44-6SDS of cas: 5765-44-6).

5-Methylisoxazole (cas: 5765-44-6) belongs to isoxazole derivatives. Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. Isoxazoles are potent isosteres of pyridine and have been found to inhibit voltage-gated sodium channels for pain control, for the construction of tetracycline antibiotic derivatives, and as a therapeutic agent for depression.SDS of cas: 5765-44-6

Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem