10558-25-5, 4-Bromo-3,5-dimethylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 106: (3, 5-Dimethyl-1, 2-oxazol-4-yl) boronic acidTo a 500 mL three RB flask fitted with magnetic stirrer was charged 4-bromo-3,5- dimethyl-1 ,2-oxazole(4.0g, 22.7 mmol) in THF(40 mL), cooled -78 C. To the stirred solvent was added n-butyl lithium (28.4 mL, 1.6M solution, 45.0 mmol) drop wise and stirred at – 65 C about 30 minutes. The RM was brought to -78 C, was added tri-isopropyl borate (12.81 g, 68.0 mmol), once the temperature to reached room temperature and stirred about 16h. Then removed the solvent under reduced pressure and quenched with saturated NH4CI solution and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous Na2S04 and removed the solvent under reduced pressure. The obtained crude material was purified by silica gel column chromatography to obtain white solid. (0.4 g, yield: 12.5%)., 10558-25-5
10558-25-5 4-Bromo-3,5-dimethylisoxazole 318421, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; CONNEXIOS LIFE SCIENCES PVT. LTD.; RANGANATH RAO, Jagannath Madanahalli; ARUMUGAM, Nagarajan; ANSARI, Mohd Mudabbir; GUDLA, Chandrasekhar; PACHIYAPPAN, Shanmugam; RAMALINGAM, Manivannan; GEORGE, Jenson; ARUL, George Fernanda; BOMMEGOWDA, Y, Kenchegowda; ANGUPILLAI, Sathesh Kumar; KOTTAMALAI, Ramamoorthy; JIDUGU, Pradeep; RAO, D, Shivanageshwara; WO2012/11125; (2012); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem