With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1136-45-4,5-Methyl-3-phenylisoxazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
5.0 g of commercially-available ArgoGel-MB-CHO ResinR (0.4 mmol/g) was suspended in DMF (20 ml) and AcOH (1.0 ml), and then methylamine hydrochloride (405 mg) and NaBH(OAc)3 (2.12 g) were added thereto in order, and stirred at room temperature for 12 hours. The reaction mixture was filtered, and the residual resin was washed with DMF, MeOH, THF and methylene chloride in that order twice each, and then dried. Dewatered methylene chloride (30 ml) was added to the thus-obtained resin to suspend it therein, and then N,N-diisopropylethylamine (5.2 ml), 5-methyl-3-phenylisoxazole-4-carboxylic acid (2.03 g) and DMC (1.70 g) were added thereto in that order, and stirred at room temperature for 1 hour. The reaction mixture was filtered, and the residual resin was washed with DMF, MeOH, THF and methylene chloride twice each, and then dried to obtain the resin of formula (II).
1136-45-4, 1136-45-4 5-Methyl-3-phenylisoxazole-4-carboxylic acid 14343, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1408042; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem