Synthesis and biological evaluation of new series of quinazoline derivatives as EGFR/HER2 dual-target inhibitors was written by Jiao, Xiaoyu;Zhang, Qing;Zhang, Yue;Shao, Junlan;Ding, Lei;Tang, Chunlei;Feng, Bainian. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2022.Synthetic Route of C7H12N2O This article mentions the following:
It is generally believed that EGFR/HER2 dual-target inhibitors may overcome the resistance of EGFR TKIs caused by HER2 overexpression. The structure-based synthesis and biol. evaluation of quinazoline derivatives as EGFR/HER2 dual-target inhibitors has been studied in this paper. I, II, III, IV displayed comparable inhibitory potency against EGFR and HER2 and I showed remarkable antiproliferative activities against NCI-H358/PC-9/Calu-3/NCI-H1781 (EGFR IC50 = 0.30 nM, HER2 IC50 = 6.07 nM, NCI-H358 GI50 = 23.30 nM, PC-9 GI50 = 1.95 nM, Calu-3 GI50 = 23.13 nM NCI-H1781 GI50 = 41.61 nM). In the experiment, the researchers used many compounds, for example, 3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9Synthetic Route of C7H12N2O).
3-(tert-Butyl)isoxazol-5-amine (cas: 59669-59-9) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. The weakness of this bond allows the ring opening of these heterocycles under reductive conditions. Isoxazole can be synthesised via a variety of methods. Examples include via the reaction of hydroxylamine with 1,3-diketones or derivatives of propiolic acid.Synthetic Route of C7H12N2O
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem