Wang, Ze-bo published the artcileApplication of parecoxib sodium combined with fentanyl in surgery of nucleus pulposus of lumbar intervertebral disc, Computed Properties of 198470-85-8, the publication is Xiandai Zhenduan Yu Zhiliao (2016), 27(10), 1801-1803, database is CAplus.
Objective: To analyze the effect of parecoxib sodium combined with fentanyl in surgery of nucleus pulposus of lumbar intervertebral disk, so as to provide reference for clin. anesthesia. Methods: A total of 78 patients undergoing surgery of nucleus pulposus of lumbar intervertebral disk in our hospital from July 2014 to Feb. 2015 were selected as the research subjects, and were divided into a study group and a control group, according to the time of admission. Patients in the study group took parecoxib sodium combined with fentanyl for analgesia, and patients in the control group took fentanyl for analgesia. The analgesia before anesthesia (T0), needle piercing the back skin (T1), disk fibrosis edge (T2), window opening (T3), nucleus pulposus removal (T4), and radiofrequency ablation time (T5) was analyzed. Results: At T0, there were no significant differences in MAP (mean arterial pressure), HR (heart rate) or SpO2 (blood oxygen saturation), and no significant difference in VAS scores (P > 0.05). At T1-T5, the MAP of the study group was significantly lower than that of the control group (P < 0.05). At T1-T5, the HR of the study group was significantly lower than that of the control group (P < 0.05), and the SpO2 of the two groups did not change significantly (P > 0.05). At T1-T5, the VAS score of the study group was significantly lower than that of the control group (P < 0.05). The incidence (15.4%) of addnl. drugs in the study group was significantly lower than that (35.9%) in the control group (P < 0.05). There were no adverse reactions such as nausea or lethargy in the two groups of patients during treatment and after surgery. Conclusion: The use of parecoxib sodium combined with fentanyl in patients undergoing surgery of nucleus pulposus of lumbar intervertebral disk has a good analgesic effect and can reduce the dosage of fentanyl, which has practical value.
Xiandai Zhenduan Yu Zhiliao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C26H26N4O7, Computed Properties of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem