Wu, Yun-xiang’s team published research in Linchuang Mazuixue Zazhi in 31 | CAS: 198470-85-8

Linchuang Mazuixue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C6H17NO3Si, Computed Properties of 198470-85-8.

Wu, Yun-xiang published the artcileEffects of parecoxib sodium on postoperative cognitive function in elderly patients undergoing gastrointestinal surgery, Computed Properties of 198470-85-8, the publication is Linchuang Mazuixue Zazhi (2015), 31(4), 320-322, database is CAplus.

Objective: To investigate the effects of parecoxib sodium on postoperative cognitive function in elderly patients undergoing gastrointestinal surgery. Methods: Forty-five patients, aged 60-75 yr, for gastrointestinal surgery, were randomly divided into 3 groups: control group (group C), 40 mg parecoxib sodium group (group P1) and 80 mg parecoxib sodium group (group P2). Group C were given normal saline, groups P1 and P2 were given parecoxib sodium 40 mg 30 min i.v. before surgery. Then only in group P2 parecoxib sodium 40 mg injected 90 min after the first given. Then blood samples taken from the right jugular bulb for IL-6, TNF-α and Aβ of plasma concentration determination by ELISA at 30 min before surgery (T0), 2 h (T1) and 6 h (T2) after the first given and 24 h (T3) after the surgery. Cognitive function was assessed by Mini-Mental State Examination (MMSE) at 24 h before anesthesia and 24 h and 48 h after surgery. Results: Compared with group C, plasma concentrations of IL-6, TNF-α and Aβ in groups P1 and P2 were lower significantly (P<0.05); MMSE scores in groups P1 and P2 at 24 h and 48 h were significantly increased, but there was no significant difference between groups P1 and P2. Conclusion: Parecoxib sodium given before surgery could inhibit the perioperative cytokine responses within cerebral blood vessel in elderly patients undergoing gastrointestinal surgery and decrease the development of postoperative cognitive function.

Linchuang Mazuixue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C6H17NO3Si, Computed Properties of 198470-85-8.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem