Kang, Kai published the artcileComparison of different doses of sufentanil combined with two non-steroidal analgesics for postoperative analgesia of gynaecology laparotomy, COA of Formula: C19H17N2NaO4S, the publication is Beijing Yixue (2015), 37(7), 654-657, database is CAplus.
Objective: To compare the post-operative analgesic effect and adverse reactions of flurbiprofen axetil and parecoxib sodium combined with different doses of sufentanil for gynecol. surgery. Methods: Be marked, 80 adult female patients who received endotracheal intubation general anesthesia downlink procedure were randomly divided into the flurbiprofen axetil 50 mg + 5 μg sufentanil group (F1), flurbiprofen axetil 50 mg + 10 μg sufentanil group (F2) and parecoxib sodium 40 mg + 5 μg sufentanil group (P1), parecoxib sodium 40 mg + 10 μg sufentanil group (P2), 20 cases in each group. All patients were treated with general anesthesia induction and intraoperative maintenance, 10 min before the end of surgery in the drug group, slow i.v. injection was conducted, then i.v. analgesia pump tube were connected and patients were transferred to the anesthesia recovery room. The MAP and HR and spontaneous breathing recovery time, open time, extubation time, the T2 to T6 VAS pain score, Ramsay sedation scores and Riker – SAS agitation score were recorded at the following time points end of surgery (T0), tube drawing immediate (T1), 5 min after extubation (T2), 10 min after extubation (T3), 2 h after surgery (T4), postoperative 4 h (T5), postoperative 6 h (T6). Results: The MAP and HR at the T1 and T2 point of P1 group was significantly higher than that of the other three groups (P < 0.05), and the rest there parameters had no statistical significant difference at each point; The F2, P2 spontaneous breathing recovery time was longer than the other two groups (P < 0.05). The open time, extubation time of the four groups of patients was not statistically significantly different. The VAS score in T2 of the P1 group was obviously higher than that of the other three groups (P < 0.05). At T6 point, F1 VAS score was higher than the other three groups (P < 0.05); The F2 of P2 Ramsay sedation scores in T3 point was higher than the other two groups (P < 0.05). Conclusion: Non-steroidal analgesics combined with low doses of sufentanil can be fully used in postoperative i.v. analgesia cohesion, compared with flurbiprofen axetil, this combination has quick effect onset, and parecoxib sodium can maintain analgesia for much longer time.
Beijing Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, COA of Formula: C19H17N2NaO4S.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem