Wang, Ka published the artcileEffect of parecoxib sodium on intravenous anesthesia with propofol-fentanyl of gynecological laparoscopic surgery, Application In Synthesis of 198470-85-8, the publication is Xiandai Shengwuyixue Jinzhan (2014), 14(16), 3142-3144, 3166, database is CAplus.
The effect of parecoxib on i.v. anesthesia with propofol-fentanyl of patients undergoing gynecol. laparoscopic surgery was evaluated. Sixty patients (ASA I or II, 21053 years old, 41-72 kg) who were undergoing gynecol. laparoscopic surgery were selected and randomly divided into two groups: parecoxib group (group P) who were received i.v. parecoxib sodium and group NS who were received normal 0 mL before anesthesia induction for 15 min, 30 cases of each group. The same anesthetic induction method was used in the two groups. Bispectral index (BIS) was used as the index of depth of anesthesia, by which the target plasma concentration of propofol was adjusted to maintain the anesthesia. HR, MAP were recorded, recovery time, extubation time, the incidence of postoperative adverse reactions and VRS after extubation for five min were recorded. Compared with group NS, MAP at T3 to T6, HR at T3 to T5 in group P were lower, and there were statistically significant difference between two groups (P<0.05). The recovery time and extubation time showed no differences between group P and group NS. The incidence of agitation and the VRS score were decreased in group P, and there were statistically significant difference between two groups (P<0.05). Preemptive analgesia with parecoxib sodium can decrease the changes in hemodynamics, incidence of agitation and the VRS score from i.v. anesthesia with propofol-fentanyl in patients who were undergoing gynecol. laparoscopic surgery.
Xiandai Shengwuyixue Jinzhan published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C16H14O6, Application In Synthesis of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem