Gu, Xiaoxia published the artcileThe clinical effect of dexmedetomidine combined with parecoxib sodium on sedation, antianxiety and prevention of intubation stress in patients undergoing functional endoscopic sinus surgery: a randomised controlled trial, Related Products of isoxazole, the publication is BMC Anesthesiology (2020), 20(1), 166, database is CAplus and MEDLINE.
One hundred twenty patients undergoing endoscopic sinus surgery were randomly divided into four groups: group DP, group D, group P and group N. Ramsay sedation score in group D,DP was significantly higher than that in group P and group N, BIS, BP, HR and anxiety scores were significantly lower than those in the group P and group N. There was no significant difference in Ramsay sedation score, BIS value, anxiety score and BP, HR between group D and group DP. Compared with T4, there was no significant difference in BIS and BP, HR in group D, group DP and group P, but BIS, BP and HR in group N were significantly higher than T4. Three minutes after intubation there was no statistical difference in changes of Cor, E, NE and BS values compared with before intubation in group P and group DP (p > 0.05), but the changes of Cor, E, NE and BS values were significantly lower than that in group N. Compared with T0, values of NE, E, Cor, BS decreased in group D, DP and P at T4, group DP decreased more significantly than group D, while NE, E, Cor, BS of T6 are at same level as the base value. In group N, NE, E, Cor, BS of T4 were at the same level of T0, but significantly higher at T6. And at T6, NE and E in group D, P and N were significantly different from those in group DP.
BMC Anesthesiology published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Related Products of isoxazole.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem