Elinson, Michail N. published the artcileElectrochemically Induced Facile and Efficient Multicomponent Approach to Medicinally Relevant 4-[4-oxo-4H-pyran-2-yl](aryl)-methylisoxazol-5(2H)-one Scaffold, SDS of cas: 1076-59-1, the publication is ChemistrySelect (2020), 5(20), 5981-5986, database is CAplus.
The new electrochem. induced multicomponent assembling has been accomplished: the electrocatalytic transformation of aldehydes R1CHO (R1 = 4-chlorophenyl, pyridin-3-yl, naphthalen-1-yl, etc.), 3-aryl-substituted isoxazol-5(4H)-ones I (R2 = H, Br, Cl, F) and kojic acid has been carried out in n-propanol in an undivided cell in the presence of sodium bromide. This transformation proceeds with the selective formation of the earlier unknown substituted 4-([3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl]-(aryl)methyl)-isoxazol-5(2H)-ones II in 57-93% yields with 190-310% current efficiency. This new electrocatalytic process provides a facile and efficient way to the separated C-aryl-substituted spacer 3-arylisoxazol-5(4H)-ones I and kojic acid pharmacol. active heterocyclic fragments, which are promising compounds II [R1 = Ph, R2 = Br; R1 = 3-methylpheny, R2 = Br; R1 = 4-(methoxycarbonyl)phenyl, R2 = Br; R1 = 4-nitrophenyl, R2 = F] for different biomedical applications, and, in particular, for regulation of inflammatory as was shown by docking studies in this research.
ChemistrySelect published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, SDS of cas: 1076-59-1.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem