Zhang, Yan published the artcileObservation of parecoxib sodium combined with midazolam in prevention of restlessness after endoscopic surgery, Computed Properties of 198470-85-8, the publication is Zhongguo Linchuang Yanjiu (2014), 27(3), 316-318, database is CAplus.
Objective To observe the effect of parecoxib sodium combined with small dose of midazolam in prevention of restlessness after endoscopic surgery. Random 90 patients receiving general anesthesia for elective endoscopic sinus surgery were divided into P, PM, C groups with 30 cases in each group, and before the end of 30 min of endoscopic sinus surgery, P group was given i.v. parecoxib sodium 40 mg, PM group was given i.v. parecoxib sodium 40 mg + midazolam 0.02 mg/kg, and group C was given i.v. injection of saline. The breathing recovery time, eye opening time, extubation time; and MAP and HR values at extubation (T1) and 5 min (T2) after extubation and 10 min (T3) after extubation were detected, and the restlessness score (RS), Ramasay sedation score (RSS), and visual analog scale (VAS) at postoperative 6h, 12h and 24h were recorded. Results The MAP and HR values at T1-T3 were superior in PM group (P<0.05); RS, RSS and VAS values at different time points in PM group were lower than P group and C group (P<0.05); the breathing recovery time, eye opening time and extubation time had no difference among the three groups (P>0.05). There were 14 cases of nausea and 11 cases of vomiting in C group; 12 cases of nausea and 9 cases of vomiting in P group; 8 cases of nausea and six cases of vomiting in PM group; nausea and vomiting was similar among the three groups (P>0.05). Conclusion Parecoxib combined with low-dose midazolam anesthesia may be effective in preventing endoscopic surgery restlessness, and can be safely used for analgesia after endoscopic sinus surgery.
Zhongguo Linchuang Yanjiu published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C6H17NO3Si, Computed Properties of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem