Generation of an 4-Isoxazolyl Anion Species: Facile Access to Multifunctionalized Isoxazoles was written by Morita, Taiki;Fuse, Shinichiro;Nakamura, Hiroyuki. And the article was included in Angewandte Chemie, International Edition in 2016.Name: Isoxazol-4-ol The following contents are mentioned in the article:
A direct functionalization of unsubstituted isoxazole was achieved by generation of 4-isoxazolyl anion species I. An efficient 4-iodination of isoxazole and halogen-metal exchange reaction using a turbo Grignard reagent (iPrMgCl·LiCl) were essential for the generation of I, which reacted with various electrophiles to give 4-functionalized isoxazoles in good to high yields. Isoxazolyl boronate, boronic acid, and stannane were also synthesized as useful building blocks from unsubstituted isoxazole. The current methods enabled us to synthesize multi-functionalized isoxazoles by introducing each substituent into the desired positions. Furthermore, total synthesis of triumferol, which was isolated from Triumfetta rhomboidea, was achieved from unsubstituted isoxazole in only three steps. This study involved multiple reactions and reactants, such as Isoxazol-4-ol (cas: 80348-66-9Name: Isoxazol-4-ol).
Isoxazol-4-ol (cas: 80348-66-9) belongs to isoxazole derivatives. Isoxazoles are aromatic heterocycles containing an N–O bond. Isoxazoles are commonly used as enaminoketone or β-diketone surrogate. As with isoxazolines, isoxazoles may be cleaved using low-valent titanium obtained from the Kulinkovich reaction.This procedure affords enaminoketones from 2,4-substituted isoxazoles.Name: Isoxazol-4-ol
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem