Luo, Si-jia published the artcileEffect of oxycodone combined with parecoxib sodium on pain relief after laparoscopic cholecystectomy, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Zhongguo Xiandai Putong Waike Jinzhan (2017), 20(10), 814-815, 818, database is CAplus.
To explore the safety of oxycodone combined with parecoxib sodium in laparoscopic cholecystectomy. According to the random number table method, 102 patients who were to undergo laparoscopic cholecystectomy were divided into a control group and an observation group, with 51 cases in each group. The control group was anesthetized with morphine combined with parecoxib sodium. The observation group was anesthetized with oxycodone combined with parecoxib sodium. The pain conditions of the two groups of patients were evaluated at 3, 12, 24, and 48 h after the operation, and the number of PCA compressions and the addnl. analgesics in the two groups within 48 h after the operation were recorded. At 3, 12, 24, and 48 h after surgery, the difference in pain scores during resting and coughing between the two groups was statistically significant (P < 0.05). The number of effective PCA compressions and the addnl. rate of analgesic drugs in the observation group within 48 h after surgery were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions in the observation group was 11.8%, which was significantly lower than the 37.3% in the control group (P < 0.05). During laparoscopic cholecystectomy, the use of oxycodone combined with parecoxib sodium anesthesia can not only achieve better anesthesia and analgesia, but also reduce the occurrence of adverse reactions, thereby ensuring the safety of patients.
Zhongguo Xiandai Putong Waike Jinzhan published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Recommanded Product: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem