Chalyk, Bohdan A. published the artcileRegioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles, Formula: C5H3F2NO3, the publication is Journal of Organic Chemistry (2019), 84(23), 15212-15225, database is CAplus and MEDLINE.
A facile synthetic route towards either 3- or 5-fluoroalkyl-substituted isoxazoles or pyrazoles containing an addnl. functionalization site was developed and applied on a multigram scale. The elaborated approach extends the scope of fluoroalkyl substituents for introduction into the heterocyclic moiety, and uses convenient transformations of the side chain for incorporation of fluoroalkyl substituted azoles into the structures of biol. active mols. The utility of the obtained building blocks for isosteric replacement of alkyl-substituted isoxazole and pyrazole was shown by the synthesis of fluorinated Isocarboxazid and Mepiprazole analogs.
Journal of Organic Chemistry published new progress about 1935503-24-4. 1935503-24-4 belongs to isoxazole, auxiliary class Difluoromethylated Building Blocks, name is 3-(Difluoromethyl)isoxazole-5-carboxylic acid, and the molecular formula is C5H3F2NO3, Formula: C5H3F2NO3.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem