Tang, Ni published the artcileEffect of paricoxib sodium on postoperative cognitive function in elderly depression rats, Product Details of C19H17N2NaO4S, the publication is Yiyao Daobao (2016), 35(1), 12-15, database is CAplus.
Objective To investigate the effect of paricoxib sodium on postoperative cognitive dysfunction (POCD) in elderly depression rats. Methods The total of 36 elderly male Sprague Dawley (SD) rats were divided into 3 groups: normal control group (n = 6); surgical group (Sur group, n = 15); paricoxib sodium group (Pare group, n = 15). Depression models were established in rats except those in the normal control group. The 5 mg·kg-1 paricoxib sodium was i. p. injected in the Pare group 1 h prior to, 8 h, 2 d and 3 d post operation, resp. And 0.9% sodium chloride injection was i. p. injected into the Sur group. Behavior and cognition of all animals were evaluated by open-field, sucrose consumption and Morris water maze tests. IL-6 and IL-1β expression were detected by Elisa. Results The escape latency was (39.98±8.93) s in Pare group vs (47.15±10.87) s in Sur group (P<0.05); and the space exploration was (24.17±8.52) s vs (20.96±9.58) s (P<0.05). IL-6 expression was (72.86±6.82) in Pare group vs (79.26±4.19) ng·L-1 in Sur group, IL-1β expression was (350.73±28.04) vs (423.35±26.81) ng·L-1 (P<0.05). The horizontal and vertical scores were significantly higher in Pare group than those in the Sur group (P<0.05). The sucrose consumption and sucrose preference were higher and the water consumption was lower in Pare group than those in the Sur group (P<0.05). Conclusion Parecoxib sodium may improve postoperative cognition of elderly rats with depression, which being associated with decrease of IL-6 and IL-1β expression in hippocampus.
Yiyao Daobao published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C5H8N2O, Product Details of C19H17N2NaO4S.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem