Hellmuth, Tina published the artcileRegioselective Catalytic Asymmetric C-Alkylation of Isoxazolinones by a Base-Free Palladacycle-Catalyzed Direct 1,4-Addition, Recommanded Product: 3-Phenylisoxazol-5(2H)-one, the publication is Angewandte Chemie, International Edition (2015), 54(9), 2788-2791, database is CAplus and MEDLINE.
Herein the first catalytic asym. alkylations of isoxazolinones I [R1 = Me, n-Pr, Ph, PhCH2, 2-naphthylmethyl, etc.; R2 = Me, Ph, 4-O2NC6H4, etc.; R1R2 = (CH2)4] with vinyl ketones R3C(O)CH:CH2 (R3 = Me, Et, Ph, 4-MeOC6H4, PhCH2CH2) forming isoxazolones II with all-C-substituted quaternary stereocenter are reported. The present studies were driven by the question of how to control the regioselectivity in the competition of various nucleophilic positions. The investigation of a direct 1,4-addition uncovered that a sterically demanding palladacycle catalyst directs the reactivity in the absence of a base nearly exclusively to the nucleophilic C atom, while at the same time it allows for high enantioselectivity and TONs up to 1900.
Angewandte Chemie, International Edition published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H7NO2, Recommanded Product: 3-Phenylisoxazol-5(2H)-one.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem