Qiu, Liang-cheng published the artcileEffects of preemptive parecoxib sodium versus flurbiprofen axetil on blood coagulation, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Linchuang Mazuixue Zazhi (2014), 30(11), 1087-1090, database is CAplus.
The effects of preemptive parecoxib sodium and flurbiprofen axetil on blood coagulation in patients undergoing radical mastectomy for breast cancer were compared. Ninety patients undergoing selective radical mastectomy were randomly allocated to three groups: 30 were injected with parecoxib sodium 40 mg (group P), 30 with flurbiprofen axetil 50 mg (group F) and 30 with normal saline (group N), each 10 mL during 10 min before induction of anesthesia. Total i.v. target-controlled infusion of remifentanil and propofol was used for anesthesia. Normal saline was the only liquid during operation. Three groups received patient controlled i.v. analgesia (PCIA) with sufentanil after surgery. Venous blood samples were taken from upper extremity before and at 30 min, 1 h, 3 h and 6 h after parecoxib, flurbiprofen axetil or normal saline administration for coagulation test, platelet count (Plt) and platelet aggregation rate (PAR), and the adverse reactions were recorded during 24 h after surgery. After 30 min of drugs administration, thrombin time (TT) of three groups was significantly extend (P<0.05); and fibrinogen (Fib) of groups F and N reduced significantly (P<0.05), which was significantly lower than that of group P (P<0.05). There were no significant differences between the other time points of coagulation parameters, Plt and PAR. The incidences of nausea arid vomiting within 24 h after surgery in groups P and F were reduced significantly compared with group N (P<0.05), the incidences of dizziness, sweating and itching had no differences, and there were no adverse reactions of gastrointestinal bleeding/ulcers and respiratory depression in all there groups. As to 50 mg of flurbiprofen axetil, preemptive parecoxib sodium 40 mg can temporarily enhance blood coagulation in patients undergoing radical mastectomy for breast cancer.
Linchuang Mazuixue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Application of Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem