Domagalina, Eugenia; Slawik, Tomasz published the artcile< Acylation of benzoxazolin-2-ones and 3-hydroxy-1,2-benzisoxazoles>, COA of Formula: C7H5NO2, the main research area is acylation bromobenzoxazolinone bromohydroxybenzisoxazole; benzoxazolinone bromo acylation; hydroxybenzisoxazole acylation; benzisoxazole hydroxy bromo acylation; CNS depressant carbethoxybenzisoxazolinone preparation; analgesic carbethoxybenzisoxazolinone preparation; anticonvulsant carbethoxybenzisoxazolinone preparation.
5-Bromo- and 5,7-dibromobenzoxazolin-2-ones were acylated with Ac2O, R1C6H4COCl (R1 = H, 2-Cl, 4-NO2), and R2O2CCl (R2 = Me, Et) to give primarily N-acylated products I (Brn = 5-Br, 5,7-Br2; R3 = Me, R1C6H4, R2O). The isomeric brominated 3-hydroxy-1,2-benzisoxazoles were predominantly O-acylated to give II (R3 the same as above). Exceptions were benzoxazole III and benzisoxazolinones IV (Brn = H, 5-Br, 5,7-Br2; R3 = R2O). IV (Brn = H, 5-Br; R3 = EtO) were the strongest central nervous system depressants and they also showed anticonvulsant activity. 5-Bromo-3-hydroxy-1,2-benzisoxazole and IV (Brn = H, R3 = EtO) had significant analgesic activity.
Polish Journal of Pharmacology and Pharmacy published new progress about Acylation. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, COA of Formula: C7H5NO2.
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem