Tomita, Kazuo; Sugai, Soji; Kobayashi, Tomiko; Murakami, Tadashi published the artcile< Studies on isoxazoles. VIII. Versatile syntheses and chemical properties of 3-chloroisoxazolium chlorides>, Quality Control of 21725-69-9, the main research area is isoxazolinone chlorination; chloroisoxazolium chloride preparation pyrolysis; isoxazolinethione; acid esterification amidation isoxazolium chloride.
The reaction of 4-isoxazolin-3-ones with COCl2 or ClCO2CCl3 gave 3-chloroisoxazolium chlorides in good yields, and these were converted to 4-isoxazoline-3-thiones on treatment with NaSH. Pyrolysis of 3-chloro-2-methylisoxazolium chlorides afforded 3-chloroisoxazoles. In the presence of Bu3N, 3-chloro-2-methyl-5-phenylisoxazolium chloride condensed carboxylic acids with alcs. or amines to give the corresponding esters or amides in high yields, together with 2-methyl-5-phenyl-4-isoxazolin-3-one.
Chemical & Pharmaceutical Bulletin published new progress about Amidation. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Quality Control of 21725-69-9.
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem