Csakai, Adam; Smith, Christina; Davis, Emily; Martinko, Alexander; Coulup, Sara; Yin, Hang published the artcile< Saccharin Derivatives as Inhibitors of Interferon-Mediated Inflammation>, Product Details of C7H5NO2, the main research area is saccharin derivative suppressant interferon mediated inflammation SAR.
A series of novel, saccharin-based antagonists have been identified for the interferon signaling pathway. Through in vitro high-throughput screening with the Colorado Center for Drug Discovery (C2D2) Pilot Library, we identified isothiazolone 1,1-dioxides as the basis for extensive structure-activity relationship studies. Our efforts produced a lead anti-inflammatory compound, tert-Bu N-(furan-2-ylmethyl)-N-{4-[(1,1,3-trioxo-2,3-dihydro-1λ6,2-benzisothiazol-2-yl)methyl]benzoyl}carbamate CU-CPD103 (I), as a potent inhibitor using an established nitric oxide (NO) signaling assay. With further studies of its inhibitory mechanisms, we demonstrated that I carries out this inhibition through the JAK/STAT1 pathway, providing a drug-like small mol. inflammation suppressant for possible therapeutic uses.
Journal of Medicinal Chemistry published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Cebpb, modified gene consistent with modulation of STAT1 signaling). 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, Product Details of C7H5NO2.
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem