Ueda, Mitsuru; Oikawa, Hideaki; Kawaharasaki, Naomi; Imai, Yoshio published the artcile< N,N'-Carbonyldi[1,2-benzisoxazol-3(2H)-one]: new, reactive condensing agent>, COA of Formula: C7H5NO2, the main research area is carbonyldibenzisoxazolone preparation peptide condensing agent; condensing agent carbonyldibenzisoxazolone amide peptide; ester carbonyldibenzisoxazolone condensing agent; benzisoxazolone carbonyldi preparation condensing agent.
The title compound (I) was prepared in 73% yield by treating 1,2-benzisoxazol-3-ol (II) with ClCO2CCl3 in refluxing toluene for 1 day. I was used as a condensing agent for the synthesis of amides, esters, and dipeptides under mild conditions. Thus, BzOH was condensed with H2NPh and HOPh by I in N-methyl-2-pyrrolidone containing pyridine to give 94% BzNHPh and 86% BzOPh, resp., whereas PhCH2O2C-Val-OH was condensed with H-Gly-OEt by I in CH2Cl2 at room temperature to give 87% PhCH2O2C-Val-Gly-OEt. I was also used as a reagent for the one-pot polycondensation of isophthalic acid with diamines to give polyamides.
Bulletin of the Chemical Society of Japan published new progress about Condensation reaction. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, COA of Formula: C7H5NO2.
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem