With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228690-37-6,(R)-1-Phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate,as a common compound, the synthetic route is as follows.
To a stirred solution of III-3 (190.9 mg, 0.64 mmol), III-4 (290.7 mg, 0.72 mmol), Na2CO3 (128.1 mg, 1.21 mmol) in DME/H2O (20 mL, v/v=3:1) was added Pd(dppf)Cl2 (66.4 mg, 0.09 mmol) under nitrogen. Then the solution was heated to reflux for 4 hours. After concentrated, H2O (5 mL) was added, and the mixture was extracted with EtOAc. The organic layer was combined and washed with brine, dried over Na2SO4, concentrated in vacuo. The residue was purified by column chromatography on silica gel (PE:EA=1:1) to afford III-5 (256 mg, yield: 26.9%)., 1228690-37-6
1228690-37-6 (R)-1-Phenylethyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate 66660383, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/200215; (2014); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem