So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bian, Qing-Hua; Li, Zai-Feng; Qiao, Zhen; Li, Chang-Rong; Xing, Yu-Fen; Wang, Min researched the compound: 2-Chloropyridine 1-oxide( cas:2402-95-1 ).Application In Synthesis of 2-Chloropyridine 1-oxide.They published the article 《Synthesis of 1-(2-chloro-4-pyridyl)-3-phenylurea》 about this compound( cas:2402-95-1 ) in Yingyong Huaxue. Keywords: chloropyridylphenylurea preparation. We’ll tell you more about this compound (cas:2402-95-1).
The title compound was prepared in 93.3% yield by reaction of Ph isocyanate with 4-amino-2-chloropyridine. The latter was obtained by nitration, reduction of 2-chloropyridine-N-oxide. The best conditions of the reaction were given.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem