With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32326-25-3,5-Methoxyisoxazol-3-amine,as a common compound, the synthetic route is as follows.
Example 1 A suspension of methyl chloroformate (167 mul; 2.16 mmol) and potassium thiocyanate (227 mg; 2.34 mmol) in acetonitrile (1.80 ml) was stirred at 70 C. for 30 minutes, and then 3-amino-5-methoxyisoxazole (205 mg; 1.80 mmol) was added to the suspension under stirring and ice-cooling. After stirring for 10 minutes at the same temparature and then for 15 minutes at room temperature, the reaction mixture was poured into ice-water (18ml). The precipitates formed were filtered off, washed with water, then with ether and dried under reduced pressure to give methyl 2-(5-methoxycarbonylamino-1,2,4-thiadiazol-3-yl)acetate (334 mg, yield 80.6%). m.p. 167-169 C. (MeOH) NMR delta (CDCl3): 3.73 (3H. s. COOCH3) 3.95 (3H. s. NHCOOCH3) 3.97 (2H. s. CH2) 10.50 (1H. bs. NH) IR (CHCL3)cm-1: 3406, 1736, 1549. Anal, Calcd, for C7 H9 N3 O4 S: C,36.36; H, 3.92; N,18.17(%). Found: C,36.40; H,3.94; N,18.11(%).
32326-25-3, As the paragraph descriping shows that 32326-25-3 is playing an increasingly important role.
Reference£º
Patent; Katayama Seiyakusyo Co. Ltd.; US5585494; (1996); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem