3405-77-4, 5-Methylisoxazole-3-carboxylic acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The 470mg of compound 7 was dissolved in 2ml of dichloromethane was added 0.7mL TFA, stirred at room temperature for 2 to 4 hours, and after completion of the reaction, the solvent was distilled off under reduced pressure, drained oil pump, the oil was dissolved in 2mL of dichloromethane , and then added sequentially 0.8mL triethylamine, 0.11 g of0.14 g of of HOBT and 0.2g EDCI, the reaction system was stirred for 8 to 12 hours at room temperature, after completion of the reaction, successively with 1M hydrochloric acid, saturated sodium bicarbonate, saturated brine , organic phase was collected, dried over anhydrous sodium sulfate, and then filtered to remove the sodium sulfate, the organic phase was collected and the solvent was distilled off under reduced pressure, column chromatography on flash silica gel to give compound 9 0.41g, 85percent yield.
3405-77-4, As the paragraph descriping shows that 3405-77-4 is playing an increasingly important role.
Reference£º
Patent; Tianjin International Biology Medicine United Academe; Rao, Zihe; Fu, Cheng; Yang, Haitao; Yang, Cheng; Cai, Yan; Wang, Zhe; Liu, He; Li, shuang; (30 pag.)CN105837487; (2016); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem